Indeed! We do allow play with Jokers to go to 54 for the GenCon event and also make it multiplayer for further hilarity.
The Philadelphia area was also playing Kansas City for some time, a variation where if you ever cheat you lose the game. This allowed for the deck to be mostly Bicycle, but allow some overlap with your starting posse with values. However, when those dudes start getting discarded as casualties and going back through the deck , you start to worry during lowball